Negative exercise testing was mandatory for inclusion.
Method: The Avatar trial is an investigator-initiated international prospective randomized controlled event-driven trial that evaluated the safety and efficacy of early SAVR in the treatment of asymptomatic patients with severe AS according to common criteria (valve area ≤1 cm 2 with aortic jet velocity >4 m/s or a mean trans-aortic gradient ≥40 mm Hg) and normal LV function (EF >50%). However, indications for early SAVR in asymptomatic patients with severe AS and normal left ventricular function remain debated.
Marko Banovic 1, Svetozar Putnik 2, Martin Penicka 3, Gheorghe Doros 4, Marek Deja 5, Radka Kockova 6, Martin Kotrc 7, Sigita Glaveckaite 8, Hrvoje Gasparovic 9, NIkola Pavlovic 10, Lazar Velicki 11, Stefano Salizzoni 12, Wojciech Wojakowski 13, Guy Van Camp 3, Serge Nikolic 14, Bernard Iung 15, Jozef Bartunek 16 1Cardiology, Univ Clinical Cntr of Serbia, Belgrade, Serbia, 2Cardiac Surgery, Univ Clinical Cntr of Serbia, Belgrade, Serbia, 3Cardiovascular Cntr, OLV Hosp, Aalst, Belgium, 4Dat of Biostatistics, Boston Univ Sch of Public Health, Boston, MA, 5Dpt of Cardiac Surgery, Med Univ of Silesia, Katowice, Poland, 6Dpt of Cardiology, IKEM, Prague 4, Czech Republic, 7Dpt of Cardiology, IKEM, Prague, Czech Republic, 8Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Vilnius Univ, Vilnius, Lithuania, 9Dpt of Cardiac Surgery, Univ Hosp Cntr Zagreb, Zagreb, Croatia, 10Dpt of Cardiology, UHC Sestre milosrdnice, Zagreb, Croatia, 11Institute of CV Diseases, Univ of Novi Sad, Sremska Kamenica, Serbia, 12Dpt of Cardiac Surgery, Univ Hosp Torine, Torino, Italy, 13Divison of Cardiology and Structural Heart Disease, Med Univ of Silesia, Katowice, Poland, 14CorDynamix, CorDynamix, Redwood City, CA, 15Dpt of Cardiology, Bichat Hosp, Paris, France, 16OlV Hosp, Cardiovascular Cntr, Aalst, Belgiumīackground: There is a class I indication for surgical aortic valve replacement (SAVR) in symptomatic patients with severe aortic stenosis (AS). Customer Service and Ordering Informationġ6219: Aortic Valve Replacement versus Watchful Waiting in Asymptomatic Severe Aortic Stenosis: The Avatar Trial.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).